New targets to prevent diabetic eye disease identified
2 Nov 2009, 1145 Hrs

Add comment          Mail          Print          Write to Editor

London, Nov 2 Scientists at Joslin Diabetes Center have found a new, independent pathway that can offer targets for preventing and treating diabetic eye disease.

In diabetes patients, high blood glucose levels can end up killing certain cells in the eyes and kidneys, which is why diabetes is the leading cause of adult blindness and of kidney failure.

In the past, scientists identified one main route for this destruction-high glucose produces oxidative stress through the NF-kB molecular pathway-but success has been elusive for drugs targeting that pathway.

"Previously it was thought that oxidants are the major pathway, but antioxidants don't seem to work in clinical trials," Nature quoted Dr. George L. King as saying.

"That clinical observation made it clear that we don't know all the mechanisms involved," says Dr. Pedro Geraldes, lead author for the paper.

Geraldes studied the effects on retinal pericytes (supportive tissue cells found near small blood vessels) in a bid to expand the search for what goes wrong as glucose levels climb.

For a long time, scientists have known that the protein PDGF, a growth factor, is essential to a cell-survival pathway that is required to keep these retinal cells alive.

Working both in cultured cells and diabetic animals, the researchers traced a molecular cascade that ends up increasing the expression of a novel target, the protein SHP-1, which de-activates PDGF activity and thus triggers cell death.

"What's exciting is that we finally have an explanation for why antioxidant drugs may not work, because there's a parallel pathway. We'll need an inhibitor of SHP-1 together with antioxidants to have a realistic chance of preventing or stopping diabetic eye disease," said King.

"We think this is also applicable to diabetic kidney disease, because we observed a similar increase in SHP-1 in the kidneys of diabetic animals," he added.

Additionally, understanding the role that SHP-1 plays in cell survival pathways may shed light on studies of cancer and other diseases, he said.

The study has been published in Nature Medicine. (ANI)

Related Latest

Bamboo fencing on Nainital's hillside roads to prevent mishaps Indian Navy vessel on solo circumnavigation of world reaches New Zealand 'Aggressive' development must to prevent return of terror in FATA: Zardari PCB undecided on sending Misbah to New Zealand Uttar Pradesh to run new medical colleges under PPP RSS not interfering in choosing new president, says BJP Pak PM says new Afghan policy should not affect regional balance Over 30,000 Indians visited New Zealand during 2008-09 Tila Tequila strips naked in new video 25 new dengue cases reported in Delhi

Related Latest

US to give crucial information on Headley-Rana accomplice's 26/11 role to India Restoration of Mughal road in J-K heads towards completion China wants a Chinese version of Tibetan Buddhism, says Dalai Lama Cultural heritage of Manipur showcased in Sikkim Green Park stadium's scoreboard, the only manually operated scoreboard in India Dalai Lama hopes PM will discuss Tibet issue with the U.S. leadership 3 injured in fire at Jodhpur's handloom showroom White House prepares for first state visit by Manmohan Singh Bamboo fencing on Nainital's hillside roads to prevent mishaps Indian Navy vessel on solo circumnavigation of world reaches New Zealand

• US to give crucial information on Headley-Rana accomplice's 26/11 role to India
• Restoration of Mughal road in J-K heads towards completion
• Cultural heritage of Manipur showcased in Sikkim
• Green Park stadium's scoreboard, the only manually operated scoreboard in India
• White House prepares for first state visit by Manmohan Singh

• भारतीय क्रिकेट की मजबूत दीवार
• कंगारूओं के आगे ढेर, चीतों से कैसे मुकाबला करेंगें शेर
• Reducing greenhouse gases may not be enough to slow global warming
• बीकानेर महापौर चुनावः एक विश्लेषण
• Deepawali: The Festival Of Lights