Washington, Nov 20 High irradiances of low-level laser therapy (LLLT) can worsen skin cancer, and thus should not be used over melanomas, say researchers.

Researchers from Bergen University College, Norway, studied the pain relieving, anti-inflammatory 'cold laser', finding that it caused increased tumour growth in a mouse model of skin cancer.

Jan M. Bjordal from Bergen University College collaborated with Brazilian researchers to conduct the in vitro and in vivo experiments.

"LLLT has gained increasing popularity as a treatment for soft tissue injuries and joint conditions. However, there is a shortage of evidence, especially in vivo evidence, about the effects of LLLT in malignant conditions such as melanoma," he said.

Bjordal and his colleagues applied LLLT to cancer cultures and to mice injected with melanoma cells.

They found that although the treatment did not cause any significant changes in the cell cultures, direct irradiation of the tumour with high-dose LLLT caused a significant increase in tumour mass volume and considerable histological alterations, indicating a worsening of the cancer, in the mice.

The researchers said: "A high irradiance (2.5W/cm2) combined with high dose of 1050 J/cm2, can stimulate melanoma tumor growth with distinct histological features in vivo".

Bjordal said: "It is important that this contraindication is implemented into clinical practice so that LLLT can remain a safe treatment."

LLLT was pioneered in the 1970s, when it was discovered that light from low-intensity lasers causes cells to proliferate more rapidly.

It is marketed as a treatment for hair-loss, pain management, sports medicine and skin care - among many other things. Home-treatment sets are available online for unsupervised use.

The study is published in the open access journal BMC Cancer. (ANI)