Why some diseases are common in kids with older fathers
26 Oct 2009, 1134 Hrs

Add comment          Mail          Print          Write to Editor

* Education Directory * Exam Results * Who is Who * Information *Tutorials * Articles * Quote * Classified

London, Oct 26 A rare form of testicular tumour might help explain why some diseases are more common in the children of older fathers, say researchers.

The research team from University of Oxford and Copenhagen University Hospital has found a link between certain severe childhood genetic disorders and rare testicular tumours occurring in older men.

Mutations can occur in different cells of the body and at different times during life. Some, such as those, which occur in 'germ cells' (those which create sperm or eggs), cause changes, which affect the offspring.

According to the researchers, the germ cells that make the mutant gene-carrying sperm seem to be the same cells that produce the tumour.

"We think most men develop these tiny clumps of mutant cells in their testicles as they age," Nature magazine quoted lead researcher Professor Andrew Wilkie from the University of Oxford as saying.

"They are rather like moles in the skin, usually harmless in themselves. But by being located in the testicle, they also make sperm - causing children to be born with a variety of serious conditions.

"We call them 'selfish' because the mutations benefit the germ cell but are harmful to offspring," Wilkie added.

The new discovery might provide an insight into the origins of several serious conditions that affect childhood growth and development like achondroplasia and Apert, Noonan and Costello syndromes, as well as some conditions causing stillbirth.

"What we have seen so far may just be the tip of a large iceberg of mildly harmful mutations being introduced into our genome," said Wilkie.

"These mutations would be too weak and too rare to be picked up by our current technology, but their sheer number would have a cumulative effect, leading to disease," he added.

The study appears in journal Nature Genetics. (ANI)

Related Latest

Doctors often fail to detect high BP in kids with chronic kidney Beckham stayed at Galaxy to enable kids to get a "normal" schooling Green lifestyle statement: Bangalore kids cycle to school Here's why some people can't quit cocaine Bone implant raises hopes for kids with skull deformities Green lessons for school kids - in lap of nature Why bird flu has not become a pandemic Why hepatitis B hits men harder than women Common pain relief drugs promote cancer growth Toddlers, fat kids suffer most from secondhand smoke

Related Latest

Brit woman turns her back on lawyer's career to make easy money as hooker Ride-on lawnmowers land thousands of people in hospital every year Cat endures 3,000-mile sea journey from Egypt to UK in shipping container! Stem cells in breast milk could fulfil baby's 'genetic destiny' Wayne Rooney's gay cousin wants to be a dad Mariah Carey 'to host grand champagne party for X Factor champ' Elizabeth Hurley's India affair over? Goa all set to host IFFI from Monday A.R Rahman urge people to maintain cleanliness around Ajmer Dargah FIFA may impose World Cup ban on French 'Hand Ball' striker Henry

• Mariah Carey 'to host grand champagne party for X Factor champ'
• Elizabeth Hurley's India affair over?
• Brit woman turns her back on lawyer's career to make easy money as hooker
• Ride-on lawnmowers land thousands of people in hospital every year
• Cat endures 3,000-mile sea journey from Egypt to UK in shipping container!

• भारतीय क्रिकेट की मजबूत दीवार
• कंगारूओं के आगे ढेर, चीतों से कैसे मुकाबला करेंगें शेर
• Reducing greenhouse gases may not be enough to slow global warming
• बीकानेर महापौर चुनावः एक विश्लेषण
• Deepawali: The Festival Of Lights