New gene linked to familial testicular cancer identified
30 Jun 2009, 1154 Hrs

Add comment          Mail          Print          Write to Editor

Washington, June 30 Scientists at the National Institutes of Health claim to have identified the second gene that can increase a man's risk of familial, or inherited, testicular germ-cell cancer.

Men with a family member who had a testicular germ cell cancer are at three-to six-fold greater risk than other men of developing testicular cancer.

Although a family history of testicular cancer probably accounts for less than five percent of all testicular cancers, the careful study of rare familial cancer clusters has often led to important new understanding of the non-familial versions of the same cancer.

"This study contributes to our understanding of why testicular germ cell cancer appears to run in families," said Dr Raynard Kington, Acting NIH Director.

"The findings may also lead to new ways to identify men at high risk, as well as more effective ways to prevent and treat testicular germ cell cancer," Kington added.

According to researchers, the key pathway in this disease is the cyclic AMP pathway, which regulates how cells respond to such signals as hormones.

Drugs that affect the cyclic AMP pathway are widely available, and, in theory, could affect progression of testicular cancer.

The researchers found that seven different mutations in the gene in question, PDE11A, created abnormal versions of the PDE11A enzyme that slowed down the enzyme's destruction of cyclic AMP.

"The mutations don't cause cancer directly, but instead appear to increase an individual's susceptibility to developing a tumour," said the study's senior author, Dr Constantine Stratakis, D.Sc., chief of NICHD's Section on Endocrinology and Genetics.

"Almost one out of every five families we studied had a variation in the gene that affected its functioning," Stratakis added.

Stratakis and his colleagues analyzed the portion of the DNA from 95 familial testicular cancer patients that contains the PDE11A gene.

They found seven mutations in the cancer patients, and noted that the rate at which they were detected was much higher than that seen in the DNA of people without testicular cancer.

Stratakis said that learning how disruptions in the PDE11A enzyme lead to an increased risk of tumor formation may help researchers identify other proteins that also play a role.

The study appears in the Cancer Research. (ANI)

Related Latest

Britney's onstage miming may prompt new Oz legislation 'Combat Barbie' steps in as new Miss England First dino footprints recognized in New Zealand date back to 70 mln years McCullum spurred New Zealand thrash Pakistan by 64 runs in second ODI New approach to prevent spinal cord damage Taylor Swift re-enacts Kanye West's VMAs flare-up in new video New class of supernova explosion discovered by scientists 'Optical biopsy' could take over invasive biopsies for breast cancer detection Gene therapy helps two kids suffering from fatal brain disease Fire break in Jaipur forces Siberian birds to explore new wetlands

Related Latest

Chemicals used in industrial applications may affect cholesterol levels Now, video game that improves intelligence How to include aging population in the technology revolution Chemical that regulates circadian rhythm identified Here's how you can shoot the perfect free throw Meet Liam Gallagher, the footie star Gerard Butler desperate to remain true to his Scottish roots Thandie Newton fell in love with hubby at first sight Russell Brand tired of "Googling" himself Two police officers embark on bicycle rally to spread message of unity

• Chemicals used in industrial applications may affect cholesterol levels
• Now, video game that improves intelligence
• How to include aging population in the technology revolution
• Chemical that regulates circadian rhythm identified
• Here's how you can shoot the perfect free throw

• बीकानेर महापौर चुनावः एक विश्लेषण
• Deepawali: The Festival Of Lights
• Nine tips for nine nights
• need new prevention tech for HIV, other STIs and UP
• "Good health is India's basic need": Easier said than done Mr Prime Minister!